Legal Medicine
Volume 5, Issue 1 , Pages 34-41 , March 2003

Toluene inhalation induced 8-hydroxy-2′-deoxyguanosine formation as the peroxidative degeneration in rat organs

Received 30 September 2002 ,Revised 12 December 2002 ,Accepted 15 January 2003.

References 

  1. Ostergaard G, Hass U, Lund SP, Simonsen L. Four weeks’ inhalation exposure of Long Evans rats to 4-tert-butyltoluene: effect on evoked potentials, behaviour, and brain neurochemistry. Pharmacol Toxicol. 2000;87(1):11–17
  2. Hass U, Lund SP, Hougaard KS, Simonsen L. Developmental neurotoxicity after toluene inhalation exposure in rats. Neurotoxicol Teratol. 1999;21(4):349–357
  3. Tomas T, Wiaderna D, Swiercz R. Neurotoxicity assessment of selected organic solvents based on spontaneous and evoked cortical and hippocampal activity in rats. Int J Occup Med Environ Health. 1999;12(1):73–84
  4. Cintra A, Andbjer B, Finnman UB, Hagman M, Agnati LF, Hoglund G, et al. Subacute toluene exposure increases DA dysfunction in the 6-OH dopamine lesioned nigrostriatal dopaminergic system of the rat. Neurosci Lett. 1996;217(1):61–65
  5. De Gandarias JM, Echevarria E, Serrano R, Irazusta J, Casis L. Effect of subacute toluene administration on the enkephalinergic neuromodulatory system in rats and protective action of ganglioside treatments. Toxicol Ind Health. 1994;10(3):155–161
  6. Gotohda T, Kuwada A, Morita K, Kubo S, Tokunaga I. Elevation of steroid 5α-reductase mRNA levels in rat cerebellum by toluene inhalation: possible relation to GFAP expression. J Toxicol Sci. 2000;25(3):223–231
  7. Gotohda T, Tokunaga I, Kubo S, Morita K, Kitamura O, Eguchi A. Effect of Toluene inhalation on astrocytes and neurotrophic factor in rat brain. Forensic Sci Int. 2000;113(1–3):233–238
  8. Gotohda T, Tokunaga I, Kubo S, Morita K. Enhancement of glial cell line-derived neurotrophic factor expression in rat adrenal glands by toluene exposure. Horm Metab Res. 2000;32(8):301–305
  9. Ohkuma Y, Hiraku Y, Oikawa S, Yamashita N, Murata M, Kawanishi S. Distinct mechanisms of oxidative DNA damage by two metabolites of carcinogenic o-toluidine. Arch Biochem Biophys. 1999;372(1):97–106
  10. Murata M, Tsujikawa M, Kawanishi S. Oxidative DNA damage by minor metabolites of toluene may lead to carcinogenesis and reproductive dysfunction. Biochem Biophys Res Commun. 1999;261(2):478–483
  11. Anderson KM, Ou D, Wu YB, Jajeh A, Harris JE. Induction of type 1 programmed cell death in U937 cells by the antioxidant, butylated hydroxy-toluene or the free radical spin trap, NTBN. Leuk Res. 1999;23(7):665–673
  12. Liu L, Zhang Q, Feng J, Deng L, Zeng N, Yang A, et al. The study of DNA oxidative damage in benzene-exposed workers. Mutat Res. 1996;370(3–4):145–150
  13. Carere A, Antoccia A, Crebelli R, Di Chiara D, Fuselli S, Iavarone I, et al. Exposure to benzene and genotoxic effects among filling station attendants. Epidemiol Prev. 1995;19(62):105–119
  14. Lagorio S, Tagesson C, Forastiere F, Iavarone I, Axelson O, Carere A. Exposure to benzene and urinary concentrations of 8-hydroxydeoxyguanosine, a biological marker of oxidative damage to DNA. Occup Environ Med. 1994;51(11):739–743
  15. Ahmed-Choudhury J, Orsler DJ, Coleman R. Hepatobiliary effects of tertiary-butylhydroperoxide (tBOOH) in isolated rat hepatocyte couplets. Toxicol Appl Pharmacol. 1998;152(1):270–275
  16. Agar NS, Mahoney JR, Eaton JW. Hemolytic and microbicidal actions of diethyldithiocarbamic acid. Biochem Pharmacol. 1991;41(6–7):985–993
  17. Weisiger RA, Fridovich I. Mitochondrial superoxide dismutase. Site of synthesis and intramitochondrial localization. J Biol Chem. 1973;248:4793–4796
  18. Carlsson LM, Jonsson J, Edlund T, Marklund L. Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia. Proc. Natl Acad Sci USA. 1995;92:6264–6268
  19. Maki H, Sekiguchi M. Mut T protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature. 1992;355:273–275
  20. Brozovsky M, Winkler EG. Glue sniffing in children and adolescents. N Y State J Med. 1965;65:1984–1989
  21. Carlsson A, Lindqvist T. Exposure of animals and man to toluene. Scand J Work Environ Health. 1977;3:135–143

PII: S1344-6223(03)00004-X

Legal Medicine
Volume 5, Issue 1 , Pages 34-41 , March 2003

Article Tools

* Image Usage & Resolution