Legal Medicine
Volume 7, Issue 1 , Pages 15-23 , January 2005

Biochemical background of ethanol-induced cold susceptibility

Received 13 August 2003 ,Revised 22 April 2004 ,Accepted 5 July 2004.

References 

  1. Huttunen P. Effect of ethanol on the processes of thermoregulation. Acta Physiol Pol. 1990;41:25–31
  2. Kalant H, Le AD. Effects of ethanol on thermoregulation. Pharmacol Ther. 1983;23:313–364
  3. Andersen KL, Hellstrøm B, Lorentzen FV. Combined effect of cold and alcohol on heat balance in man. J Appl Physiol. 1963;18:975–982
  4. Graham T, Baulk K. Effect of alcohol ingestion on man's thermoregulatory responses during cold water immersion. Aviat Space Environ Med. 1980;51:155–159
  5. Kitzinger R, Risse M, Puschel K. Kälteidiotie Paradoxes Entkleiden bei Unterkühlung. Arch Kriminol. 1991;187:47–56
  6. Teresiński G, Buszewicz G, Mądro R. The influence of ethanol on the level of ketone bodies in hypothermia. Forensic Sci Int. 2002;127:88–96
  7. Brinkmann B, Fechner G, Karger B, DuChesne A. Ketoacidosis and lactic acidosis-frequent causes of death in chronic alcoholics?. Int J Legal Med. 1998;111:115–119
  8. Teresiński G, Buszewicz G, Mądro R. Usefulness of β-hydroxybutyric acid, acetoacetic acid and acetone determinations in blood, urine and vitreous humour for necrochemical diagnosis of premortal metabolic disorders. Probl Forensic Sci. 2000;44:55–69
  9. Duguid H, Simpson RG, Stowers JM. Accidental hypothermia. Lancet. 1961;2:1213–1219
  10. Hirvonen J. Necropsy findings in fatal hypothermia cases. Forensic Sci. 1976;8:155–164
  11. Mizukami H, Shimizu K, Shiono H, Uezono T, Sasaki M. Forensic diagnosis of death from cold. Legal Med. 1999;1:204–209
  12. Plyuscheva TV, Alisievich VI. Pathogenesis of Vishnevsky's spots in death from excessive cooling. Sud Med Ekspert. 2000;43(1):11–14
  13. Prokop O. Forensische medizin; Second publication. Berlin: VEB Verlag Volk; 1966.;p. 145–9
  14. Rothschild MA, Schneider V. Terminal burrowing behaviour—a phenomenon of lethal hypothermia. Int J Legal Med. 1995;107:250–256
  15. Schneider V, Klug E. Tod durch Unterkühlung. Zentralbl Rechtsmed. 1980;86:59–69
  16. Trube-Becker E. Zur Begutachtung beim Tod durch Unterkühlung. Dtsch Z ges gericht Med. 1967;59:211–227
  17. Wedin B, Vanggaard L, Hirvonen J. Padoxical undressing in fatal hypothermia. J Forensic Sci. 1979;24:543–553
  18. Doi K, Ohno T, Kurahashi M, Kuroshima A. Thermoregulatory nonshivering thermogenesis in men, with special reference to lipid metabolism. Jpn J Physiol. 1979;29:359–372[in Japanese with English abstract]
  19. Hanson PG, Johnson RE. Variation of plasma ketones and free fatty acids during acute cold exposure in man. J Appl Physiol. 1966;20:56–61
  20. Helman A, Gilbert M, Pfister-Lemaire N, Reach G, Assan R. Glucagon and insulin secretion and their biological activities in hypothermic rats. Endocrinology. 1984;115:1772–1778
  21. Hirvonen J, Huttunen P. Hypothermia markers: serum, urine and adrenal gland catecholamines in hypothermic rats given ethanol. Forensic Sci Int. 1995;72:125–133(comments in: Forensic Sci Int 1995;76:227–30)
  22. Lamke LB, Lennquist S, Liljedahl SO, Wedin B. The influence of cold stress on catecholamine excretion and oxygen uptake of normal persons. Scand J Clin Lab Invest. 1972;30:57–68
  23. Leppaluoto J, Huttunen P, Hirvonen J. The effect of deep hypothermia on the secretion of thyroid hormones and cortisol and oxygen consumption in guinea-pigs. Acta Physiol Scand. 1981;112:417–420
  24. Shephard RJ. Metabolic adaptations to exercise in the cold. An update. Sports Med. 1993;16:266–289
  25. Mayes PA. Bioenergetics and the metabolism of carbohydrates and lipids; Third publication. In:  Murray RK,  Granner DK,  Mayes PA,  Rodwell VW editor. Harper's biochemistry. 22nd ed. Warsaw: Appleton & Lange, Polish edition by PZWL; 1995;p. 198–216,see also p. 226–38, 260–73
  26. Lundquist F, Tygstrup N, Winkler K, Mellemgaard K, Munck-Petersen S. Ethanol metabolism and production of free acetate in human liver. J Clin Invest. 1962;41:955–961
  27. Plapp BV. Rate-limiting steps in ethanol metabolism and approaches to changing these rates biochemically. Adv Exp Med Biol. 1975;56:77–109
  28. Wallgren H, Barry H. Actions of alcohol. vol. 1. Amsterdam: Elsevier; 1970;
  29. Labib M. Hypoglycaemia. In:  Marshall WJ,  Bangert SK editor. Clinical biochemistry; First publication. New York: Churchill Livingstone; 1995;p. 281–294
  30. Haight JS, Keatinge WR. Failure of thermoregulation in the cold during hypoglycaemia induced by exercise and ethanol. J Physiol. 1973;229:87–97
  31. Johnston CE, Bristow GK, Elias DA, Giesbrecht GG. Alcohol lowers the vasoconstriction treshold in humans without affecting core cooling rate during mild cold exposure. Eur J Appl Physiol Occup Physiol. 1996;74:293–295
  32. Risbo A, Hagelsten JO, Jessen K. Human body temperature and controlled cold exposure during moderate and severe experimental alcohol-intoxication. Acta Anaesthesiol Scand. 1981;25:215–218
  33. Huttunen P, Hirvonen J. The effect of ethanol on the ability of guinea-pigs to survive severe cold. Forensic Sci. 1977;9:185–193
  34. Lomax P, Lee RJ. Cold acclimation and resistance to ethanol-induced hypothermia. Eur J Pharmacol. 1982;84:87–91
  35. Cornier M-A, Gayles EC, Bessesen DH. The effects of chronic ethanol consumption on energy balance in rats. Metabolism. 2002;51:87–791
  36. Murgatroyd PR, Ven MLHM van de, Goldberg GR, Prentice AM. Alcohol and the regulation of energy balance: overnight effects on diet-induced thermogenesis and fuel storage. Br J Nutr. 1996;75:33–45
  37. Suter PM, Jéquier E, Schutz Y. Effect of ethanol on energy expenditure. Am J Physiol. 1994;266:R1204–R1212
  38. Freund G. Hypothermia after acute ethanol and benzyl alcohol administration. Life Sci. 1973;13:345–349
  39. Lomax P, Bajorek JG, Chesarek WA, Chaffee RRJ. Ethanol-induced hypothermia in the rat. Pharmacology. 1980;21:288–294
  40. Myers RD. Alcohol's effect on body temperature: hypothermia, hyperthermia or poikilothermia?. Brain Res Bull. 1981;7:209–220
  41. Buszewicz G, Mądro R. Stability of toluene and reduction of acetone to 2-propanol in homogenates of the human liver, brain and lungs. Forensic Sci Int. 2004;141:63–68
  42. Denmark LN. The investigation of beta-hydroxybutyrate as a marker for sudden death due to hypoglycemia in alcoholics. Forensic Sci Int. 1993;62:225–232
  43. Fitzgerald FT. Hypoglycemia and accidental hypothermia in an alcoholic population. West J Med. 1980;133:105–107
  44. Pounder DJ, Stevenson RJ, Taylor KK. Alcoholic ketoacidosis at autopsy. J Forensic Sci. 1998;43:812–816
  45. Thomsen JL, Felby S, Theilade P, Nielsen E. Alcoholic ketoacidosis as a cause of death in forensic cases. Forensic Sci Int. 1995;75:163–171

PII: S1344-6223(04)00052-5

doi: 10.1016/j.legalmed.2004.07.002

Legal Medicine
Volume 7, Issue 1 , Pages 15-23 , January 2005